Endocrine » Thyroid & Parathyroid

Hypothyroidism

Hypothyroidism is usually a primary process resulting from failure of the thyroid gland to produce adequate amounts of hormone. It may also be caused by a lack of thyroid hormone secretion secondary to the failure of adequate thyrotropin i.e. thyroid-stimulating hormone (TSH) secretion from the pituitary gland, or thyrotropin-releasing hormone (TRH) from the hypothalamus (secondary or tertiary hypothyroidism). Patients may be largely asymptomatic or may rarely present with coma and multi-system organ failure (myxoedema coma). Classic signs and symptoms include cold intolerance, puffiness, decreased sweating, and coarse skin. Third-generation TSH assays are readily available and are generally the most sensitive screening tool for hypothyroidism. Thyroid hormone is administered to supplement or replace endogenous production.

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