Recommendations for the Prevention & Treatment of Glucocorticoid - induced Osteoporosis

Glucocorticoid-induced bone loss should be prevented, and if present, should be treated. Supplementation with calcium and vitamin D at a dosage of 800 IU/day, or an activated form of vitamin D (e.g., alfacalcidiol at 1 micrograms/day or calcitriol at 0.5 micrograms/day), should be offered to all patients receiving glucocorticoids, to restore normal calcium balance. Antiresorptive agents are effective in the treatment of glucocorticoid-induced bone loss. All of these agents either prevent bone loss or modestly increase lumbar spine bone mass and maintain hip bone mass. The therapies to prevent or treat glucocorticoid-induced bone loss should be continued as long as the patient is receiving glucocorticoids.


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