Fever is a systematic defensive response indicated by abnormally-elevated body temperature due to a resetting of the hypothalamic thermoregulatory centre. Fever may be produced by several stimuli including bacteria, viruses, protozoa, immune reactions and drugs (the exogenous pyrogens). Hyperpyrexia is elevation of temperature to unusually high levels i.e. 105.8° F (41° C) or higher. Fever is one of the best examples of responses to injury and infection which depends on neuro-immune interactions. It is a natural self-defense mechanism intended to make the host less hospitable to microscopic invaders.


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