General Medicine

Corticosteroids

Corticosteroids are synthesised in the adrenal cortical cells from cholesterol. Adrenal steroidogenesis takes place under the influence of ACTH. The corticoids have widespread actions. They maintain fluid electrolyte levels, cardiovascular and energy substrate homeostasis, and the functional status of skeletal muscles and nervous system. They prepare the body to withstand effects of noxious stimuli and stress.Prednisolone, dexamethasone and methylprednisolone are commonly used for therapeutic purposes.The adrenal cortex secretes steroidal hormones which have glucocorticoid, mineralocorticoid and weakly androgenic activities.

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