Myelofibrosis
Myelofibrosis is a rare disease of the bone marrow in which collagen builds up fibrous scar tissue inside the marrow cavity. Myelofibrosis is caused by an abnormality in a single stem cell, which causes it to proliferate. About one quarter of all patients with myelofibrosis have no symptoms (asymptomatic). An enlarged spleen discovered at an annual medical examination may be the first clue. Anaemia and leuco-erythroblastic blood picture, dry tap in bone marrow aspiration and bone marrow trephine biopsy (collagen and reticulin staining) confirms the diagnosis. Treatment is supportive and palliative.
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