Haemat Onco » Hematological malignancies

Chronic Myelogenous Leukaemia

Chronic myelogenous leukemia (CML) is a myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to The disease occurs in the fourth and fifth decades of life. The clinical manifestations of CML are insidious and are often discovered incidentally when an elevated WBC count is revealed by a routine blood count or when an enlarged spleen is revealed during a general physical examination. The increase in mature granulocytes and normal lymphocyte counts (low percentage due to dilution in the differential count) results in a total WBC count of 20,000-60,000 cells/mL. The 3-fold goals of treatment of CML are to achieve a hematologic remission, to achieve cytogenetic remission, and to achieve molecular remission.

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