Lab medicine » Hematology

HbA1C (Glycosylated Hb)

Glycosylated haemoglobin (total) is the total HbA1C which is comprised of HbA1A, HbA1B, and HbA1C, and is what most laboratories estimate. Circulating haemoglobin (Hb) in adults consist of HbA (97%); HbA2 (2.5%); and HbF (0.5%). HbA contains a number of minor Hb sub types (HbA1A, HbA1B & HbA1C), collectively known as HbA1.

All people with diabetes should have an HbA1C test at least thrice a year. People with diabetes should get the test more often if their blood sugar stays too high, or if changes are made in their treatment plan(s).

The findings of a major diabetes study, the Diabetes Control and Complications Trial (DCCT), have shown that lowering the haemoglobin A1C value can delay or prevent the development of serious eye, kidney, and nerve disease in people with diabetes. The study also showed that lowering haemoglobin A1C levels by 1% reduces the chances of microvascular complications by almost 30%-40%.The HPLC (gold standard for HbA1C) method is the only method that meets all five of the National Institutes of Health, US (NIH) recommended guidelines.

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