Anti Nuclear Antibodies

The indirect immunofluorescence has taken over from the LE cell test because it is more sensitive, simpler to perform and easier to interpret. In SLE patients ANA is positive in about 95%. Different patterns of fluorescence can be observed depending on the types and relative amounts of autoantibodies present in the sample. Low positive ANA (+) maybe seen in-patients on certain drugs like (Isoniazid, Chlorpromazine). In chronic infection and in aging 60-75% of elderly persons without apparent disease may show a low titre positively.

 

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