Lab medicine » Serology

C-Reactive Protein

Studies on relationship between ESR and CRP have suggested that CRP levels correlate better with degree of activity than ESR in certain diseases as rheumatoid arthritis (RA) and ankylosing spondylitis (AS). CRP is used in medical practice to differentiate cystitis from pyelonephritis; sarcoid from tuberculosis, Crohn's disease from ulcerative colitis and viral meningitis (< 10mg/dl) from bacterial meningitis. It is also useful in monitoring infection in neonatal sepsis, post operative patients, malignancy and SLE. In rheumatic diseases CRP accurately reflects disease activity and is used to assess this in RA, gout, psoriatic arthritis, AS etc.CRP levels are elevated above the normal range in most patients with active SLE and tend to fall as disease improves. CRP elevation in lupus patients is an indication of infection and must be expressed quantitatively.

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