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Evidence-Based Guidelines Issued to Detect and Treat Sepsis

Severe sepsis is common, with multiple organ dysfunction and very high mortality rate. In terms of the pathophysiology of severe sepsis, a cascade of inflammation and activation of the coagulation system associated with impaired fibrinolysis causes changes in microvascular circulation associated with organ dysfunction, severe sepsis, multiple organ dysfunction syndrome, and death. Timely recognition and diagnosis of severe sepsis is the first step in the management of sepsis. Use of the sepsis resuscitation and management bundles is associated with reduced mortality in patients with sepsis.

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