General Medicine

Amyloidosis

Amyloidosis is a group of diseases that result from the abnormal deposition of a particular protein, called amyloid, in various tissues of the body. Primary amyloidosis occurs when plasma cells spontaneously overproduce light chains. The deposits in the tissues of persons with primary amyloidosis are AL proteins. Secondary amyloidosis is seen in multiple myeloma, chronic infections or chronic inflammatory diseases. The amyloid tissue deposits in secondary amyloidosis are AA proteins. Familial amyloidosis is a rare form of inherited amyloidosis. The diagnosis of amyloidosis is made by detecting the characteristic amyloid protein in a biopsy specimen of involved tissue/ organ. Treatment aims at correction of organ failure and treatment of underlying illness .For primary systemic amyloidosis, aggressive treatment options include stem cell transplantation and high doses of chemotherapy

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