Allergy and Immunology » Immunology

Henoch-Schönlein Purpura (HSP)

Henoch-Schönlein purpura (HSP) is an inflammatory disorder characterised by a generalised vasculitis involving the small vessels of the skin, GI tract, kidneys and joints. Rarely it may even involve the lungs and CNS. It is thought to be an immunoglobulin A (IgA)-mediated autoimmune phenomenon. The antigen-antibody complexes deposit locally throughout the body leading to necrotizing vasculitis.

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