Cyclosporin : in Rheumatic Diseases

For the treatment of rheumatic diseases, cyclosporin is administered in a dose of 3 - 5 mg per kg daily. An effect is usually demonstrable after 1 - 3 months of treatment and a maximal response is obtained within 6 months.The important side effects are renal failure and hypertension, the drug should not be given to patients with renal failure or untreated hypertension. Serum creatinine and blood pressure are measured at 2-week intervals during the first 2 months of treatment, thereafter once a month. A more than 30% rise in serum creatinine from the baseline should lead to a reduction of the cyclosporin dose. If the increase is more than 50% the drug must be stopped. During cyclosporin therapy, the diastolic blood pressure must not rise above 100 mm Hg (occasionally antihypertensive medication is needed.


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