Allergy and Immunology » Immunology

Urticaria and Arthritis (Serum Sickness)

Serum sickness is a type III hypersensitivity reaction that results from the injection of heterologous or foreign protein or serum. Reactions secondary to the administration of non-protein drugs are clinically similar to serum sickness reactions. Primary serum sickness occurs 6-21 days after the administration of the inciting antigen. The onset may be more rapid with subsequent exposures to the same antigen, with symptoms occurring 1-4 days after exposure. The classic clinical manifestations consist of fever, arthralgia, lymphadenopathy, and skin eruption. The treatment consists of stopping the medication. Relieving the itch with antihistamines, and administration of corticosteroids.

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