Addison's disease may be caused by autoimmune adrenalitis, tuberculosis, haemorrhage, metastases or appearing as a manifestation of APECED syndrome, pituitary or hypothalamic disease, tumour, trauma and infection. Hyponatraemia is the first electrolyte disturbance in Addison's disease. Addison's crisis may affect a patient with hypocortisolism during an infection or severe stress. Hydrocortisone substitution should be immediately started.


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