Endocrine » Thyroid & Parathyroid

Thyroid Function Tests

TSH is the first-line test of thyroid function. Further tests are performed if confounding factors exist, controversial results are obtained or a thyroid disease is confirmed (an abnormal TSH). If TSH levels are above the reference range, directly measure or perform a surrogate assessment of free hormone levels using additional tests. Patients with primary hypothyroidism have elevated TSH levels and decreased free-hormone levels. Patients with elevated TSH levels but normal free-hormone levels or estimates are considered to have sub-clinical hypothyroidism. Very low TSH concentrations do not always indicates hyperthyroidism with certain exceptions. Evaluation of the presence of thyroid auto-antibodies (anti-microsomal or anti-TPO antibodies) and anti-thyroglobulin (anti-Tg) may be helpful in determining the aetiology of hypothyroidism or in predicting future hypothyroidism.

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