GI & Liver » Hepato-biliary-pancreas » Liver & Spleen

Gilbert's Syndrome

Gilbert's syndrome is the most common hereditary cause of increased bilirubin. The main symptom is otherwise harmless jaundice which does not require treatment, caused by elevated levels of unconjugated bilirubin in the bloodstream. The source of this hyperbilirubinemia is reduced activity of the enzyme glucuronyltransferase which conjugates bilirubin and some other lipophilic molecules. Conjugation renders the bilirubin water-soluble and suitable for excretion via the kidneys. It normally has no serious consequence. Mild jaundice may appear under conditions of exertion, stress, fasting, and infections. While this syndrome is considered harmless, it is clinically important because it may be confused with much more dangerous liver conditions.

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