GI & Liver » Hepato-biliary-pancreas » Liver & Spleen

Approach to a patient with Liver Dysfunction

Hepatocellular diseases (such as viral hepatitis or alcoholic liver disease) show features of liver injury, inflammation, and necrosis. In cholestatic diseases (such as gall stone or malignant obstruction, primary biliary cirrhosis, many drug-induced liver diseases), features of inhibition of bile flow predominate. Diagnosis is usually suggested by the pattern of onset and prominence of symptoms, particularly if major risk factors are considered, such as the age and sex of the patient and a history of exposure or risk behaviours.

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