Major depressive disease in adults in family practice

Depressed mood or anhedonia (diminished interest or pleasure in activities) is necessary to diagnose major depression.Presentations of depression include sleep disorder (increased or decreased)interest deficit (anhedonia), guilt (worthlessness, hopelessness, regret) energy deficit, concentration deficit, appetite disorder (increased or decreased), psychomotor retardation or agitation and suicidality. Antidepressant drug selection should be based on the patient's history of response to previous antidepressant medications (if any), the patient's comorbid psychiatric or medical conditions and clinician familiarity with specific antidepressants.


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